- Frasier, Niles, Daphne, Martin, and Roz move on to new chapters in their lives.
- Frasier faces his final curtain, uncertain of what line of work he should pursue, or even where - and most significantly, with whom. The radio station is once again undergoing a shift in management, and Roz applies for the position of station manager. David Crane enters the world, and his grandfather and Ronee Lawrence finally tie the knot - in that order.
- While on a plane, Frasier meets a woman named Anne. They engage in conversation and in flashback, Frasier recalls the events preceding his plane ride: Frasier and Niles volunteer to put together a quick wedding for Martin and Ronee when the venue is only available for one day. Meanwhile, Frasier says farewell to Charlotte as she departs for Chicago. The wedding ceremony gets off to a rocky start when the guests are stranded outside in the heat and things get worse when Eddie swallows one of the rings. Daphne and Niles rush him to a nearby veterinarian and while there, Daphne goes into labor and gives birth to her and Niles' first son, whom they name David. Ronee and Martin get married at the vet clinic. Frasier's agent Bebe Glazer gets him an offer to do a television show in San Francisco, which Frasier initially declines but after realizing that he wants to start a new chapter in his life, he accepts. A case of communication breakdowns lead Martin, Ronee, Roz, Daphne and Niles to believe that Frasier is dying, an error given more substantial backing when he begins giving them each some of his most prized possessions, and when a doctor phones and leaves a message saying that Frasier's 'results weren't good.' The misunderstanding is soon cleared up and the family celebrates Frasier's new opportunity in San Francisco. Before he leaves, Frasier and his family share a tearful farewell and Frasier explains to him that with Martin and Ronee newly-weds and Daphne and Niles' newborn, David, and Roz getting the job of station manager at KACL they each have begun a new chapter in their lives and that he wants that for himself now. He then goes on to recite Tennyson's "Ulysses" which flows into him saying it in his last show. Frasier records his last show, with the people who work at KACL and his family watching him, his final words on his talk show are "For eleven years, you have heard me say 'I'm listening'; well you were listening too, and for that I'm eternally grateful...Goodnight Seattle", and hangs up his headphones before the episode flashes back to the plane, where Frasier has just finished relaying his story to Anne. In a final twist, the plane touches down not in San Francisco, but in Chicago. Frasier turns to Anne and says "Wish me luck...", then the episode (and the series) ends, in a perpetual cliffhanger, which is divulged in the first episode of the Frasier (2023) revival.
- While on a plane, Frasier meets a woman named Anne. They engage in conversation and in flashback, Frasier recalls the events preceding his plane ride: Frasier and Niles volunteer to put together a quick wedding for Martin and Ronee when the venue is only available for one day. Meanwhile, Frasier says farewell to Charlotte as she departs for Chicago. The wedding ceremony gets off to a rocky start when the guests are stranded outside in the heat and things get worse when Eddie swallows one of the rings. Daphne and Niles rush him to a nearby veterinarian and while there, Daphne goes into labor and gives birth to her and Niles' first son, whom they name David. Ronee and Martin get married at the vet clinic. Frasier's agent Bebe Glazer gets him an offer to do a television show in San Francisco, which Frasier initially declines but after realizing that he wants to start a new chapter in his life, he accepts. A case of communication breakdowns lead Martin, Ronee, Roz, Daphne and Niles to believe that Frasier is dying, an error given more substantial backing when he begins giving them each some of his most prized possessions, and when a doctor phones and leaves a message saying that Frasier's 'results weren't good.' The misunderstanding is soon cleared up and the family celebrates Frasier's new opportunity in San Francisco. Before he leaves, Frasier and his family share a tearful farewell and Frasier explains to him that with Martin and Ronee newly-weds and Daphne and Niles' newborn, David, and Roz getting the job of station manager at KACL they each have begun a new chapter in their lives and that he wants that for himself now. He then goes on to recite Tennyson's "Ulysses" which flows into him saying it in his last show. Frasier records his last show, with the people who work at KACL and his family watching him, his final words on his talk show are "For eleven years, you have heard me say 'I'm listening'; well you were listening too, and for that I'm eternally grateful...Goodnight Seattle", and hangs up his headphones before the episode flashes back to the plane, where Frasier has just finished relaying his story to Anne. In a final twist, the plane touches down not in San Francisco, but in Chicago. Frasier turns to Anne and says "Wish me luck...", then the episode (and the series) ends, in a perpetual cliffhanger.
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