Tattoo on Focus Guy's neck is from Isaiah 58:10 -- "Feed the hungry, and help those in trouble. Then your light will shine out from the darkness, and the darkness around you will be as bright as noon."
Despite the Lois skit, Seth MacFarlane was already working on a new animated TV series with focus on female lead.
Three cast members of the FX animated series Archer (2009) guest star in this episode: Judy Greer, Chris Parnell, and H. Jon Benjamin. Benjamin is a somewhat regular guest on Family Guy as Carl the convenient store clerk and he also voices Bob from Bob's Burgers (2011) (another animated show on Fox). Benjamin has been in the recent Arby's commercials which had a product placement skit in this episode.
Meg appears but has no dialogue in this episode.
This is Zac Sawyer's third appearance after "McStroke" and "Brian's A Bad Father."