Missy (Courtney Henggeler) calls Sheldon (Jim Parsons) by his nickname, "Shelly", just like their mother (Laurie Metcalf).
Title Reference: Howard expressed he would kill his Rabbi with a pork chop to be with Missy.
Leonard, Howard and Rajesh all sit in Sheldon's spot at some point.
This is the third time that Raj (Kunal Nayyar) is able to talk to a girl. Previously, it took alcohol, another time was accidental and this time it's an experimental drug trial.
Missy tells Leonard and Howard that when they were eight years old, Sheldon tried to build an armed robot to keep her out of his room. However in Young Sheldon (2017) it is shown that Missy and Sheldon actually share a room. (Though it is possible that when Sheldon refers to "his room", he is in fact referring to his side of the room. A common distinction when siblings share a room.)