About the episode title: members of Alcoholics Anonymous are also known as "Friends of Bill W.", after Bill Wilson, one of the founders of the organization.
After taking off Stewie's fake mustache, future Peter mumbles something about "laugh and cry/f-in' cry - what's the difference?" This is a reference to an ongoing debate about a line Stewie sings in the theme song.
The song "Mr. Booze" is from the movie Robin and the 7 Hoods (1964) sung by Frank Sinatra, Dean Martin, Sammy Davis Jr., and Bing Crosby.
Peter briefly references the Nickelodeon series CatDog (1998) about a creature that is half cat and half dog. Seth MacFarlane unsuccessfully pitched a story reel for CatDog.