Da Vinci's Inquest was loosely based on the real life experiences of Larry Campbell, the former chief coroner of Vancouver, British Columbia, who was elected mayor of that city in 2002. The part of Da Vinci, however, was written specifically for actor Nicholas Campbell. Elements of the series story lines were also taken from sociopolitical issues faced by the real-life Vancouver, such as the plight of the homeless, the controversy over a designated injection site for drug users, the idea of establishing a red light district, and the disappearance of homeless women and sex workers-similar to the case of Robert Pickton.