George's attempts to get out of a painting party at the Willises' get him into plenty of trouble at a state mental hospital, where he goes crazy trying to convince everyone that he's sane. The only one who knows that George is being held by mistake is another patient.
George and Louise discover Lionel and Jenny will go to Boston if he gets a new job. Meanwhile, when Tom Willis has the flu, so George has to take, nearly 9 months pregnant Jenny, to Lamaza class. After class ends Jenny goes into labor .
The family has eagerly awaited the arrival of the newest Jefferson, but the baby may catch everyone off-guard as George frantically tries to get Jenny to the hospital while trying to get word to Lionel that his wife's in labor, in the conclusion of a two-part story.
George brags he's found the perfect gift for Jenny and Lionel's baby shower, but fails to notice that what they really need can't be bought and packaged.
The guys (George, Tom, and Lionel) are convinced taking care of a baby is child's play, but when the gals (Louise, Helen, Jenny, and Florence) leave newborn Jessica in their care, they soon discover it's a whole different ball game.
It is George's 50th birthday and he thinks that none of his friends want to celebrate with him. However, Louise have secretly invited all of his friends to he apartment building for a surprise party.
Lionel's loan on a new home does not go through; therefore, George, Louise, Tom and Helen secretly go to the banker behind each other's backs to co-sign the loan.
George puts his foot down to his landlord to gain more space for his cleaners, but only succeeds in stepping on a good friend; everyone is up-in-arms when they hear that their favorite hangout, Charley's Bar, is being forced out so someone can take over the space.
Flashback of the Jeffersons before moving to Hauser Street. George is determined to open his own dry cleaners, but is at odds with both his banker's racist attitudes and Lionel's militancy. He and Louise encourage Dr. King's nonviolence.
Anxious to receive call from a banker about a loan for inflationary times, George opts to stay and look after Jessica while the rest go to the theater to see a play, "Knights of the Longbow." To lull her to sleep, he spins a medieval tale of King George and Dark Knight Inflation.
George's doctor tells him that his blood pressure is too high and that he needs a vacation, while Tom and Helen are in Hawaii enjoying themselves enough to extend their stay for another week.
George, Louise, and Florence arrive in Hawaii, where he hides his blood pressure problem and they meet up with Tom and Helen. A native Hawaiian romances Florence. A fellow businessman convinces George to think about relocating permanently.
George, Louise, Helen, and Tom take part in a Polynesian show, but George leaves early to meet with someone about an oceanfront condominium deal. He then tries to interest Louise in a permanent relocation and is very friendly with Tom.
Florence swallows her pride and borrows money from George when her shady cousin Ernie claims to need $1000 to buy a record store and turn his life around.