An escaped killer who MacGyver is searching for, is actually the pawn of a mastermind criminal who is still locked up and planning revenge on the female detective who incarcerated him.
Once Jack Dalton finds his long-lost mother, he discovers that she is a fugitive. The police, a bounty hunter, and a corrupt government official are all determined to catch her first.
The young son of MacGyver's co-worker is kidnapped by the boy's father and taken to Canada. MacGyver must go and retrieve the boy from the house of the boy's uncle, a powerful mob boss.
Ray, an ex-gang member, gets into some trouble with the police and a local shop owner. With the help of MacGyver, he unravels a racist community in the neighborhood surrounding the challenger's club.
A teenage prostitute is trying to leave her pimp and return to her family. As MacGyver helps her to do this, it is revealed that she is also being abused by her father who blames her for the death of his wife.
A downed World War II plane in the Arctic is suspected of containing lots of gold. A joint US-Russian team goes to retrieve the gold but it turns up missing, MacGyver thinks that a US soldier is the man responsible for the crash.
MacGyver takes a group of Phoenix Foundation employees for a recreational trip into the wilderness but learns that someone of the group might be an escaped criminal.
An awards ceremony given by an African nation for help received from MacGyver and Jack, is the setting of an assassination plot of that nation's leader with Jack as the unwitting assassin.
MacGyver and Pete Thornton are caught as hostages by a terrorist group that intends to hit a city with an Electro Magnetic Pulse weapon, which would cripple the entire city.
MacGyver, Jack and Pete go to relax on a gold-panning expedition. Unfortunately, a woman from MacGyver's past stalks them and has murderous intentions in her plan of revenge.
MacGyver and his archaeologist friend continue on to London and France in their search for the Holy Rose. Along the way they come across a notorious jewel magnate who has deadly intentions.
A female defector, who is a witness to a murder, is protected by the Phoenix Foundation. She also holds the key to the location of a priceless necklace.
While in Geneva, MacGyver is wounded in an assassination attempt. He is framed as the sniper and meets an American schoolgirl who helps him in clearing his name.
Renegade America service men steal everything that's not nailed down in Thailand, creating a life-threatening situation. MacGyver helps set things right, while helping an old friend get acquainted with a son he never knew he had.
Murdoc enlists MacGyver's help to rescue his sister from his former employer. She is scheduled to be executed during a Halloween Party put on by the professional assassination organization.
MacGyver trails a friend, Billy Colton, to Africa where he witnesses the cruel slaughter of the endangered Black Rhino. When he joins the activists, hoping to prevent the poaching, Mac meets up with the men behind the scheme - Ladysmith.
A rock-star friend of MacGyver's is filming a video for the Rock Against Drugs campaign. A series of mysterious accidents that occur during filming convinces her that her twin sister is attempting to kill her.