With humanity reclaiming Earth from the Killer Tomatoes, Fang stages an uprising and ousts Zoltan from the Gang of Six. Zoltan forms a alliance once more with Dr. Gangreen, who creates five new tomatoes to fight against Fang's crew.
The KTTF and Gang of Six trade places which leads to the newly-tomatoed Wilbur and his team being on the run while the now-human Gang of Six plan on putting the African Tomato Worms on ice.
After a plot to splatter Chad with tomatoes goes awry, Zoltan and the Gang of Five rebel against Dr. Gangreen and take up racketeering to enslave some of San Zucchini's businesses.
Dr. Gangrene creates a group of tomato sharks. The Tomato Task Force can't stop them from wreaking havoc on San Zucchini harbor. It's up to Chad, Tara and F.T. to blast the tomatoes.
Dr. Gangreen reveals the story of a childhood enemy named Sidney Igotcha whose tricks led to Gangreen's obsession with tomatoes. Now he's back and created a new enemy aimed at his own attempts at world conquest.