House and the team must determine what is causing an increasingly deceitful patient's muscle flailing. Stacy makes a decision, and Cameron avoids a test.
A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
The search for the cause of a supermodel's symptoms causes intense feelings among the team, as new facts are revealed. Meanwhile, House experiences increasing pain in his leg.
House must diagnose a man who became sick and experienced difficulty breathing during sex-play but all tests keep returning normal. Wilson experiences close-up what living with House is like. Clinic case: Herpes
6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean bedroom after her boyfriend almost kisses her and discovers something on her arm.
On a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
Cameron gets mad at Foreman because Foreman steals his idea for an article. The case of the week: a lesbian woman has not slept for ten days despite taking a bottle of sleeping pills.
A dad kisses his wife and baby goodbye before leaving for work, pukes and returns to find his wife with seizure in the bathtub and the baby under water. Foreman is back but changed.
House cares for a young Katrina victim, the alleged daughter of an old friend of his. He supposes she has hallucinations because of the heart, but it turns out not to be the cause. House discovers a disease that her grandfather had.
Richard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.
A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
A husband and wife being treated cause Foreman to ponder the strength of true love, and House abuses one too many patients with potentially devastating repercussions.
An obese man in a coma presents treatment challenges, but finding out what's wrong with him may be the most challenging test of all. Elsewhere, Tritter ramps up his vendetta against House.
When the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
A young man collapses at his job, and House makes a game of establishing the diagnosis until things turn critical, and Tritter increases the pressure on Wilson.
Wilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.