Leo is preparing for his future with Cris when he gets bad news. New patients Nina (cancer), Bea (coma) and Chicco (accident) arrive. Vale avoids his friends and his follow-up appointments. Toni gets a job at the hospital.
Leo makes a choice that devastates Cris, while Vale meets someone new. Leo helps Nina adjust. Flam, a blind girl, arrives for surgery and makes an impression on Chicco. Vale faces his fears, while Leo's elderly friend Nicola collapses.
Leo and Cris cope with her return to the hospital, while Nina recovers from surgery. Nicola gives Leo an important task. Leo and Vale deal with their falling out, while Rocco helps Bea in her coma. Chicco teaches Flam about colors.
A medical crisis involving Cris reunites the Red Bracelets. Cris finds out what Leo has been hiding. While celebrating his 18th birthday, Leo gets more bad news.
Leo leaves the hospital with some of the group to fulfill Nicola's request, but Leo hasn't told them everything. Toni makes a special connection. Rocco stays at the hospital to help Chicco, Flam, and Bea with their issues.