Mikey and Bunsen have to find Boodles, Bunsen's invisible dog, after Amanda lures him away from home. Bunsen's best friend Wolfie comes to visit Muckledunk and has his eyes and stomach set on Mikey.
When Bunsen eats Amanda's universal remote, he and Mikey have to rescue her from her malfunctioning smart house. Mikey and Bunsen compete against Amanda for the chance to have their own segment on the local news channel.
Bunsen proves bees are the best spellers when he turns into one and wins the spelling bee. When MMA fighter, Jerry The Beast, picks Bunsen to be his new mascot, Mikey has to prove that he is a beast too.
Mikey and Bunsen help Amanda pass the Preparatory Overview Of Pupils test so she can avoid summer school. Mikey enters Bunsen into the Muckledunk Mutt Show, but Amanda tries to sabotage them and win with her robot dog.
It's Bunsen and Cosmo's Friend-iversary, so Bunsen excitedly takes Mikey to meet him in Dimmsdale, while Amanda secretly follows. The group has a great time, until Mr. Crocker and Amanda team up and decide to take them down.
Bunsen tries to help Mikey overcome his fear of the woods during an overnight camping trip. Amanda tries to sabotage Mikey and Bunsen after they are appointed the new hall monitors.
Mikey discovers that Bunsen is about to hibernate for 50 years! The only way Mikey can save Bunsen is to keep him up past his appointed hibernation time. Mikey and Bunsen go on a shopping spree adventure at "I've So Gotta Have It" store.
Mikey and Bunsen are forced apart after Miss Flap changes the seating chart to mix things up. When Bunsen is hypnotized by swirling toilet water, Amanda tries to convince him to return to Beast World.
When Amanda learns of Bunsen's strong fear of thunder, she devises a plan to scare him out of Muckledunk. Bunsen wants to win pies for Mikey, but Bunsen starts to lose his memory after getting a case of the hiccups.