The rescue receives two new residents Professor Clovis, a miniature schnauzer with a suspected liver shunt who needs a complicated and costly surgery and Hamburglar, a blind puppy who Amanda prepares for his new forever family.
Amanda and her kids travel to Hawaii, where they meet dogs perfect for Panda Paws: a deaf mother-daughter Catahoula duo, Loco Moco, a puppy who may be blind, and Super Scootie, a senior in need of a home after years of neglect.
Amanda finds forever homes for her Hawaiian rescues. Super Scootie has malformed legs among other problems and Loco Moco struggles to process visual cues. A new rescue arrives Lily Rose, a blind and overweight toy spaniel.
Amanda travels to California to pick up special needs dogs at a local SPCA. She comes home with a Rottweiler puppy with a severe eye injury, a husky shepherd mix covered in maggots and two small puppies whose ears have fallen off.
Felines take over when Amanda helps an energetic kitten facing euthanasia after breaking his leg for a second time, along with a tiny kitten born with malformed front legs. A 3-legged Husky-Rottweiler pup needs a forever home.
Amanda works with Tia of Pit Bulls & Parolees to rescue a 3-legged Shepherd mix as part of a road trip rescue mission. She picks up 16 dogs along the way, including a young lab with a brain issue and a puppy mill survivor.
A member of Amanda's TV crew wants to adopt a Frenchie who lived her entire life in a puppy mill. Cupid, a lab mix puppy, needs daily physical therapy for a brain disorder, and a pittie from Amanda's past needs emergency surgery.
Amanda faces one of her most challenging rescues when a puppy arrives with serious neurological issues. Panda Paws helps a Chihuahua terrier mix bounce back after only having the use of one leg before finding him a forever family.
Amanda teams up again with Tia of Pit Bulls and Parolees to help Aiden, a Great Dane mix with a brain issue. Then, she meets Chickpea, a French bulldog with a medical condition that quickly turns into a life or death situation.